A study that took children and adolescents who had cystic fibrosis and tried the following three levels of supplementation (explained further after the list):
<150 µg/d (low; multivitamins/no supplement)
150–999 µg/d (middle; CF-specific vitamins)
1000 µg/d
So the first level was a low daily intake from food and/or a typical multivitamin. The second level was subjects taking multivitamin designed for cystic fibrosis. The last group took high levels of vitamin K.
Comparing the blood levels of vitamin K to "healthy" children and adolescent (so not necessary optional vitamin K status, just "normal") the only group to achieve these normal levels was the high group with 1000 µg/d.
What I found amazing is that this research wasn't undertaken till this year. I would have naively assumed that before a multivitamin preparation was advertised as a specific cystic fibrosis multi they would have undertaken these tests to determine what level to use. Clearly not.
Reference: Kelly A Dougherty, Joan I Schall and Virginia A Stallings Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis Am J Clin Nutr (June 16, 2010). doi:10.3945/ajcn.2010.29350
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