Secondly they used a high daily dose of zinc, 45 mg. To put that is perspective the RDI, depending on country is about the 15 mg level. So this is 3x the RDI of zinc.
Thirdly they supplemented for 6 months. This means that the bodies stores had time to stabilize and the body had a chance to rebuild/repair or overcome any issues that lack of zinc might have caused.
Thus they were focusing on maximizing any effect. This is a great study as often supplement trials aren't double blind placebo, don't focus on already healthy, don't supplement high enough levels and have a very short time frame. Hence the results for supplementation can be variable.
What did they find a reduction in the markers for oxidative stress and inflammation across a whole range of markers, proteins, cells etc. For those who like the jargon the reduction was across:
- High-sensitivity C-reactive protein (hsCRP)
- Iinterleukin (IL)-6,
- Macrophage chemoattractant protein 1 (MCP-1)
- Vascular cell adhesion molecule 1 (VCAM-1)
- Secretory phospholipase A2
- Malondialdehyde and hydroxyalkenals (MDA+HAE)
These findings suggest that zinc may have a protective effect in atherosclerosis because of its antiinflammatory and antioxidant functions
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